File Format:

• Manuscript files must be in DOC, DOCX, or RTF format.
• Microsoft Word documents should not be locked or protected.

Length:

• Manuscripts can be of any length, without restrictions on word count, figures, or supporting information. However, Authors are encouraged to present and discuss their findings concisely.

Font:

• Use any standard font size and standard font, except for the font named "Symbol."
• To add symbols to the manuscript, use the Insert → Symbol function in your word processor or paste in the appropriate Unicode character.

Headings:

• Limit manuscript sections and sub-sections to 3 heading levels.
• Ensure heading levels are clearly indicated in the manuscript text and must be numbered.

Layout and Spacing:

• Manuscript text should be double-spaced.
• Do not format text in multiple columns.

Page and Line Numbers:

• Include continuous page numbers and line numbers in the manuscript file.

Footnotes:

• Footnotes are not allowed in the manuscript. Move any footnote information into the main text or the reference list, as appropriate.

Language:

• Manuscripts must be submitted in English.
• Translations of the manuscript or abstract may be submitted as supporting information, following the supporting information guidelines.

Abbreviations:

• Define abbreviations upon first appearance in the text.
• Avoid non-standard abbreviations unless they appear at least three times in the text.
• Keep abbreviations to a minimum.

Reference Style:

• Follow the "Vancouver" style, as outlined in the ICMJE sample references.
• Refer to reference formatting examples and additional instructions.

Equations:

• Use MathType for display and inline equations whenever possible.
• If MathType is not available, Equation Editor or Microsoft's Insert → Equation function is acceptable.
• Avoid using equation tools for single variables, symbols, or mathematical operators in running text. Use Unicode values for single symbols.
• Include the entire equation, avoiding hybrid inline or display equations.

Nomenclature:

• Use correct and established nomenclature whenever possible.
• Units of Measurement:
• Use SI units exclusively. If other units are used, provide the SI value in parentheses.

Drugs:

• Provide the Recommended International Non-Proprietary Name (rINN) for drugs.

Species Names:

• Write species names in italics (e.g., Escherichia coli).
• Write out the full genus and species name in the title and at the first mention of an organism in the paper. After the first mention, use the first letter of the genus name followed by the full species name (e.g., E. coli).

Genes, Mutations, Genotypes, and Alleles:

• Write gene names in italics. Use recommended names from appropriate genetic nomenclature databases (e.g., HGNC for human genes).
• Indicate synonyms for the gene the first time it appears in the text.
• Gene prefixes (e.g., v-fes, c-MYC) should be in roman typeface.

Allergens:

• Use the systematic allergen nomenclature of the WHO/IUIS Allergen Nomenclature Sub- committee for manuscripts involving allergenic proteins.
• For manuscripts describing new allergens, obtain approval from the WHO/IUIS Allergen Nomenclature Sub-Committee before publication.

SECTIONS IN MANUSCRIPTS

Manuscripts submitted for research and review articles in the journal should be divided into the following sections:

Title Page

• The title of the article should be Specific, descriptive, concise, and comprehensible to readers outside the field and must not be more than 150 characters.
• Authors should avoid the use of non-standard abbreviations and question marks in titles.
• Titles should be written in sentence case (only the first word of the text, proper nouns, and genus names are capitalized)
• According to the reporting guidelines, information about the study should be a part of the title (particularly for systematic reviews and meta-analyses).
• Authors should also provide a short 'running title with no more than 100 characters' stating the topic of the study.
• Title page will have full names (First name, Middle name and Last name/surname) of all authors with affiliation (department, university, or organizational affiliation and its location, including city, state/province (if applicable), and country) and ORCID iD.
• In the end details of corresponding author(s), i.e., full names, complete affiliation/postal address, along with phone, fax and email.
• If an author has multiple affiliations, enter all affiliations on the title page only. In the submission system, enter only the preferred or primary affiliation. Author affiliations will be listed in the typeset PDF article in the same order that authors are listed in the submission.

Structured Abstract

After title page comes the abstract structured according to the followings:

1. Describe the main objective(s) of the study
2. Explain how the study was done, including any model organisms used, without methodological detail
3. Summarize the most important results and their significance
4. Must not exceed 300 words
5. Abstracts should not include: Citations and Abbreviations (if possible)

Keywords

Provide 6 to 8 keywords from the manuscript which may be part of title, repeated several times in the text and likely to appear in search of the relevant field.

Introduction

The introduction should start from new page. It should be comprehensive preferably providing background that puts the manuscript into context and allows readers outside the field to understand the purpose and significance of the study. Defining the problem addressed and why it is important. Including a brief review of the key literature. Concluding with a brief statement of the overall aim of the work and a comment about whether that aim was achieved.

Materials and Methods

Results

The important and main findings of the study should come first in the Results Section. The tables, figures and references should be given in sequence to emphasize the important information or observations related to the research. The repetition of data in tables and figures should be avoided. Results should be precise.

Discussion

Conclusion

A small paragraph summarizing the contents of the article, presenting the final outcome of the research or proposing further study on the subject, may be given at the end of the article under the Conclusion section.

List of Abbreviations

Consent for Publication

Availability of Data and Materials:

• The datasets generated and/or analyzed during the study are available in the [NAME] repository, [PERSISTENT WEB LINK TO DATASETS].
• The datasets used and/or analyzed during the study are available from the corresponding author upon reasonable request.
• All data generated or analyzed during the study are included in the published article and its supplementary information files.
• The datasets generated and/or analyzed during the study are not publicly available due to specific reasons (mention the reason), but they are available from the corresponding author upon reasonable request.
• Data sharing is not applicable to this article as no datasets were generated or analyzed during the study.
• The data that support the findings are available from [third party name], but restrictions apply. Data are available from the authors upon reasonable request with permission from [third party name].
• If your manuscript does not contain any data, state "Not applicable."

Conflict of Interest

All individuals involved in the peer review process, including authors, editors and reviewers are required to declare any potential competing interests. Competing interests can be financial or non-financial, professional, or personal. Competing interests can arise in relationship to an institution, organization, or another person. Where authors have no competing interests, the statement should read “The author(s) declare(s) that they have no competing interests”.

Acknowledgements

References

Journal References

Accepted, unpublished articles

Frumin AM, Nussbaum J, Esposito M. Functional asplenia: demonstration of splenic activity by bone marrow scan. Blood 2023; epub ahead.

Preprint

Krick T, Shub DA, Verstraete N, Ferreiro DU, Alonso LG, Shub M, et al. Amino acid metabolism conflicts with protein diversity. arXiv:1403.3301v1 [Preprint]. 2014. Available from: https://128.84.21.199/abs/1403.3301v1​

Book:

Plewig G, French L, Ruzicka T, Kaufmann R, Hertl M. Braun-Falco´s Dermatology. 4 th ed. Germany: Springer; 2000. pp. 1053–82.

Chapter In Book:

Wyllie AH, Kerr JFR, Currie AR. Cell death: the significance of apoptosis. In: Bourne GH, Danielli JF, Jeon KW, Eds. International review of cytology. London: Academic; 1980. p. 251-306.

Masters' Theses Or Doctoral Dissertations

Wells A. Exploring the development of the independent, electronic, scholarly journal. M.Sc. Thesis, The University of Sheffield. 1999. Available from: http://cumincad.scix.net/cgi-bin/works/Show?2e09

Patent

Lebold TP, Dvorak CA, Coate HR, Ziff JM, Preville C, Shireman BT. Substituted 2-azabicycles and their use as orexin receptor modulators. WO2016040789A1 (2016).

Conference Proceedings

Appendices:

• This section If you have lengthy but essential methodological details to present, use appendices.
• Appendices are part of the article but must be kept concise, not exceeding three pages.
• Use Times New Roman font, 10-point size, with a maximum of 900 words per page.
• Title a single appendix as "APPENDIX," and if there are multiple appendices, label them as "APPENDIX A," "APPENDIX B," and so on.

Supportive/Supplementary Material:

List supporting information captions at the end of the manuscript file. Do not submit captions in a separate file. Authors may use almost any description as the item name for a supporting information file as long as it contains an “S” and number. For example, “S1 Appendix” and “S2 Appendix,” “S1 Table” and “S2 Table,” and so forth. Authors can submit essential supporting files and multimedia files along with their manuscripts. All supporting information will be subject to peer review. Submit all supportive material in a single zipped file, not exceeding 4 MB in size. Additional files will be linked to the final published article but not displayed within the paper itself.

Figures:

The figures submitted with the manuscript must be of good quality in any version of PDF, PPT, MS Word, TIFF or JPEG. Manuscripts with Blur and distorted images will not be acceptable. Embed the illustrations directly within the text file of your manuscript. Figure captions must be inserted in the text of the manuscript, immediately following the paragraph in which the figure is first cited (read order). Do not include captions as part of the figure files themselves or submit them in a separate document. A figure label with Arabic numerals, and “Figure” abbreviated to “Fig” (e.g. Fig 1, Fig 2, Fig 3, etc). Match the label of your figure with the name of the file uploaded at submission (e.g. a figure citation of “Fig 1” must refer to a figure file named “Fig1.tif”).

If a figure consists of multiple parts, combine them into a single composite illustration file. Ensure all numbers, symbols, and letters in your figures are consistent and clear throughout, and they should be large enough to remain readable even when the size is reduced for publication.

Scaling/Resolution:

Accepted File Formats:

You can use various file formats for your illustrations, such as:

Avoid Using: To maintain the quality and clarity of your figures, please avoid using the following formats and practices:

• Graphics embedded in word processor documents (e.g., Word, Excel, PowerPoint).
• Optimized files for screen use (e.g., GIF, BMP, PICT, WPG) due to their low resolution.
• Files with excessively low resolution that may compromise visibility.
• Graphics that are disproportionately large for the content, which can lead to formatting issues.

Tables

Publication Fee